"Ass Backwards" is an irreverent female buddy comedy about two childhood best friends who are pushing the age of 30 and not quite where they thought they'd be in life. When they run into their former beauty pageant nemesis, they decide to go on a road trip back home to recapture the pageant crown which eluded them as children. On the road, they face some hard truths about themselves and each other as they encounter spring breakers, strip clubs, a women's militant group and their favorite reality star. This heightened comedic awakening leads us into an unforgettable third act finale that is the girls' homecoming and final reckoning with their past, present and future.

When Dennis Cooverman gives the commencement speech at his graduation, his friend tells him to let it all out. So he proclaims his love for Beth Cooper the head cheerleader, and reveals things about everyone in the graduating class as well as some other people. Later Beth confronts him and he invites her to a graduation party at his house. And to his surprise she and two of her friends show up. But also some of the people he offended with his speech. And one of them is Beth's boyfriend who she just broke up with. So they all get in Beth's car and drive away. And what follows is wild adventure.